DOI: http://dx.doi.org/10.18203/issn.2454-2156.IntJSciRep20221052

Clinical study of non-gall stone induced pancreatitis in a tertiary care centre

Varun Dogra, Rabia Nazir Ahmed, Javid Ahmad Peer, Ishfaq Ahmad Gilkar

Abstract


Background: Acute pancreatitis is a serious condition caused by an acute inflammatory cascade in the pancreas usually with symptoms of upper abdominal pain and increased pancreatic enzymes in blood, urine, peritoneal fluid at least 3 times above the normal. Presence of permanent, morphologic and functional damage differentiates acute and chronic pancreatitis. Aims and objectives: The aims and objectives of this study was to study the aetiology of non-gall stone induced pancreatitis.

Methods: It was an observational hospital-based study, which was designed and conducted in the department of general surgery, school of medical science and research, Sharda University, Greater Noida.

Results: The mean age of study population was 33 years. Among 100 patients 5 patients were in age group of ≤20 years, 47 in 21-40 years, 31 in 41-60 years and 17 in >60 years. The study consisted of 100 patients among which the male to female ratio was 1.7. In our study, in 18% of the patient’s alcohol was found to be the causative agent of acute pancreatitis. Hypertriglyceridemia and drugs as causative factor were seen in 15 and 7 patients respectively. No cause could be identified in 30% subjects.

Conclusions: Acute pancreatitis is a disease with high morbidity and mortality throughout the globe. Among the non-gall stone induced pancreatitis idiopathic and alcohol was found to be the commonest causative factor followed by others.


Keywords


Pancreatitis, Amylase, CT scan

Full Text:

PDF

References


Forsmark CE, Baillie J, AGA Institute Clinical Practice and Economics Committee, AGA Institute Governing Board. AGA Institute technical review on acute pancreatitis. Gastroenterology. 2007;132:2022-44.

Yang AL, Vadhavkar S, Singh G, Omary MB. Epidemiology of alcohol-related liver and pancreatic disease in the United States. Arch Intern Med. 2008;168:649-56.

Alsamarrai A, Das SL, Windsor JA, Petrov MS. Factors That Affect Risk for Pancreatic Disease in the General Population: A Systematic Review and Meta-analysis of Prospective Cohort Studies. Clin Gastroenterol Hepatol. 2014;12(10):1635-44.

Lee JK, Enns R. Review of idiopathic pancreatitis. World J Gastroenterol. 2007;13:6296-313.

Lehmann GA, Sherman S. Diagnosis and therapy of pancrease divisum. Gastrointest Endosclin N Am. 1998;8(1):55-77.

Sherman S, Lehman G. Sphincter of oddi dysfunction-giagnosis and treatment. J Pancrease. 2001;2.

Yang L, He Z, Tang X, Liu J. Type 2 diabetes mellitus and the risk of acute pancreatitis: a meta-analysis. Eur J Gastroenterol Hepatol. 2013;25:225-31.

Milheiro A, Medeiros A, Castro F. Acute pancreatitis-an analysis of consecutive 91 cases (1988-1991) with a brief review of literature. Acta Med Port. 1995; 12(10):1635-44.

Chang MC, Su CH, Sun MS, Huang SC, Chiu CT, Chen MC et al. Etiology of acute pancreatitis – a multi-center study in Taiwan. Hepatogastroenterol. 2003;50(53):1655-7.

Lee SP, Nicholls JF, Park HZ. Biliary sludge as a cause of acute pancreatitis. N Engl J Med. 1992;326(9):589-93.

Alsamarrai A, Stephanie AL, John A, Maxim S.Factors that affect risk for pancreatic diseases in the General Population: A Systemic Review and Meta-analysis of Prospective Cohort Studies. Clin Gastroenterol Hepatol. 2014;12:1635-44.