DOI: http://dx.doi.org/10.18203/issn.2454-2156.IntJSciRep20202097

A study on mean anion gap over 6 hours after admission as a predictor of pediatric mortality in pediatric intensive care unit

Mayank Jain, Priya Jain, Sandeep Narayan Lal, Vivek Ranjan

Abstract


Background: The aims of the study was to correlate change in anion gap at 0 and 6 hours of admission with mortality in pediatric intensive care unit (PICU).

Methods: Fifty children up to 12 years of age, admitted in PICU were included in the study. Blood gas anion gap levels were taken at 0 and 6 hours of admission and change in anion gap was calculated. Final outcome was recorded.  

Results: Out of 50 patients enrolled in the study, 18 (36%) patients died and 32 (64%) survived. Mortality was higher in group with increased anion gap after 6 hours of admission as compared to survived. Change in anion gap was higher in expired patient as compared to survivors.

Conclusions: Mortality was higher in group with increased anion gap after 6 hours of admission.


Keywords


Anion gap, Lactates, Mortality, PICU, Blood gas

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References


Andersen LW, Mackenhauer J, Roberts JC, Berg KM, Cocchi MN, Donnino MW. Etiology and Therapeutic Approach to Elevated Lactate Levels. Mayo Clin Proc. 2013;88(10):1127-40.

Jhamb U, Jat K, Gupta V. Serum lactate levels as the predictor of outcome in pediatric septic shock. Indian J Crit Care Med. 2011;15(2):102-7.

Munde A, Kumar N, Beri RS, Puliyel JM. Lactate clearance as a marker of mortality in pediatric intensive care unit. Indian Pediatr. 2014;51(7):565-7.

Lee S, Kang KP, Kang SK. Clinical Usefulness of the Serum Anion Gap. Electrolyte Blood Press. 2006;4(1):44-6.

Fernandez A, Ruiz J, Jesus DN, Garay GJ, Ramos PA, Barroso I. 984: anion gap as a predictive value for clinical outcome in critically ill children. Crit Care Med. 2015;43:247.

Kim MJ, Kim YH, Sol IS, Kim SY, Kim JD, Kim HY, et al. Serum anion gap at admission as a predictor of mortality in the pediatric intensive care unit. Sci Rep. 2017;7(1):1456.

Kaplan LJ, Kellum JA. Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury. Crit Care Med. 2004;32(5):1120-4.

Duke TD, Butt W, South M. Predictors of mortality and multiple organ failure in children with sepsis. Intensive Care Med. 1997;23(6):684-92.