DOI: http://dx.doi.org/10.18203/issn.2454-2156.IntJSciRep20211043

Oral cancer chemoprevention: COX-2 inhibitor a covenant

Shashi Keshwar, Sonal Grover, Daya Shankar, Deependra Prasad Sarraf

Abstract


Oral cancer survival remains poor despite advancement in treatment modalities. In oral cancer and oral premalignant lesions, cyclooxygenase-2 (COX-2) is widely expressed and tends to be enhanced especially in high-risk oral lesions. Numerous researches suggests that the inflammation pathway of cyclooxygenase/prostaglandin E2 (PGE2) leads to the development and progression of a number of cancers, including oral squamous cell carcinoma (OSCC). With an emphasis on research data, this article discusses the relationship between inflammation and cancer, summarizes the use of anti-inflammatory agents COX-2 inhibitors for cancer chemoprevention and treatment, and explains the mechanisms underlying the anti-cancer effects of anti-inflammatory agents (COX-2 inhibitors).


Keywords


COX-2 inhibitor; Inflammation, Oral cancer

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References


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