Role of iron metabolism in pulmonary tuberculosis: a case control study in Katra

Authors

  • Chandan Sharma Department of Medicine, Sub-District Hospital, Akhnoor, Jammu, Jammu and Kashmir, India
  • Ashima Badyal Department of Biochemistry, Government Medical College, Jammu, Jammu and Kashmir, India

DOI:

https://doi.org/10.18203/issn.2454-2156.IntJSciRep20211946

Keywords:

Pulmonary Tuberculosis, Mycobacterium Tuberculosis, Iron Metabolism

Abstract

Background: Tuberculosis (TB) disease still carries an appreciable mortality, representing the world’s second leading cause of death from a single infectious agent. In a living organism, iron (Fe) is an essential micronutrient, as a co-factor of enzymes and involved in various cellular functions. Fe homeostasis is maintained by various mechanisms is disturbed in diseased. The aim of study was estimating the Fe metabolism in pulmonary tuberculosis patients in relation to sputum bacterial load and inflammation and severity.

Methods: This present case control study was conducted in department of medicine CHC Katra, Jammu, Jammu and Kashmir from June 2019 to September 2019. A total of 100 adult patients diagnosed with pulmonary TB (PTB) and 74 healthy, age matched individuals were included in the study.

Results: Out of 100 patients, 65% were males with average age being 43.56±15.63 years. Mean serum protein at 6.32±0.78 g/dl and mean serum albumin at 3.45±0.52 g/dl showed significance. Mean serum Fe (39.68±18.32 ug/dl) and mean hemoglobin level (9.36±1.52) was significantly lower as compared to controls. Serum TIBC, serum ferritin and serum CRP showed higher values among cases. Raised serum ferritin levels corresponded to the raised CRP and TB is seen causing significantly low levels of transferrin.

Conclusions: CRP and ferritin should be regarded as useful markers of PTB activity and also to the risks associated to it and also while monitoring therapeutic response.

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Author Biographies

Chandan Sharma, Department of Medicine, Sub-District Hospital, Akhnoor, Jammu, Jammu and Kashmir, India

Department of Medicine, Sub-District Hospital, Akhnoor, Distt. Jammu, J&K, India

Ashima Badyal, Department of Biochemistry, Government Medical College, Jammu, Jammu and Kashmir, India

Assistant Professor,

Department of Biochemistry

GMC Jammu

References

MacNeil A, Glaziou P, Sismanidis C, Maloney S, Floyd K. Global Epidemiology of Tuberculosis and Progress Toward Achieving Global Targets-2017. Morb Mortal Wkly Rep. 2019;68(11):263-6.

Isanka S, Mugusi F, Urassa W, Willett WC, Bosch RJ, Villamor E, et al. Iron deficiency and Anemia predict mortality in patients with tuberculosis. J Nutr. 2012;142(2):350-7.

Castellano AD, Muniain A, Rodriguez-Bano J, Garcia M, Rios MJ, Galvez J, et al, Factors associated with time to sputum smear conversion in active pulmonary tuberculosis. Int J Tuberc Lung Dis. 2003;7(5):432-8.

WHO/UNICEF/UNU. Iron deficiency anaemia: assessment, prevention and control, a guide for programme managers, Geneva, WHO, 2001. Available at: http://www.who.int/nutrition/ publications/micronutrients/anaemia. Accessed on 13 April 2021.

Kim J, Resnick MW. The role of iron metabolism in lung inflammation and injury. J Aller Ther. 2012;4:004.

Cancado RD, Chiattone CS. Anemir da doenca cronica. Res Bras Hematol Hemoter. 2002;24(2):127-36.

Ratledge C. Iron, mycobacteria and tuberculosis. Tuberculosis. 2004;84(1-2):110-30.

Akiibinu MO, Arinola OG, Ogunlewe JO, Onih EA. Non-enzymatic antioxidant and nutritional profile in newly diagnosed pulmonary tuberculosis patients in Nigeria. Afr J Biomed Res. 2007;10(3):223-8.

Breen RAM, Leonard O, Perrin FMR, Smith CJ. How good are systemic symptoms and blood inflammatory markers at detecting individuals with tuberculosis? Int J Tuberc Lung Dis. 2008;12(1):44-9.

Gil-Santana L, Cruz LAB, Arriaga MB, Miranda PFC, Fukutani KF, Silveira-Mattos PS, et al. Tuberculosis-associated anemia is linked to a distinct inflammatory profile that persists after initiation of antitubercular therapy. Sci Rep. 2019;9:1381.

Festus OO, Omon E, Dada FL, Eidangbe G, Iweka FJ. Evaluation of some trace elements in patients with active pulmonary tuberculosis attending central hospital, Benin city, Eda state. Euro J Pharmaceut Med Res. 2016;3(9):37-43.

Lee CH, Goag EK, Lee SH, Chung KS, Jung JY, Park MS, et al. Association of serum ferritin levels with smoking and lung function in the Korean adult population: analysis of the fourth and fifth Korean national health and nutrition examination survey. Int Int J Chron Obstruct Pulmon Dis. 2016;11:3001-6.

Huang HH, Yan HC, Han CL, Yu FC, Kao W, Chen W, et al. Association of in vitro oxidative stress, serum ferritin concentration and C-reactive protein in febrile emergency room patients. Clin Invest Med. 2005;28(2):48-54.

Mishra S, Taparia P, Yadav D, Koolwal F. Study of iron metabolism in pulmonary tuberculosis patients. Int J Health Sci Res. 2018;8(3):70-7.

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Published

2021-05-24

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Original Research Articles