Effect of lockdown due to COVID-19 pandemic on lipid profile of Indian male population

Subrat K. Tripathy, Subhashree Ray


Background: SARS-COV-2 pandemic is one of the biggest health challenges for modern era and this type of pandemic was never witnessed in recent past. To control the pandemic various measures were taken by various authorities like lockdown and shutdown. This study was meant to find the effect of this new way of social isolation during lockdown on Indian male population.

Methods: The study was conducted in IMS and SUM hospital, Bhubaneswar, Odisha. Those having routine blood check-up before lockdown in the hospital were again re-evaluated for their lipid profile after lockdown. Only male between age group of 20 to 59 included in the study who were mostly confined to home during lockdown.  Female, front line workers and people already having deranged lipid profile were excluded from the study.

Results: It was found that there are significant variations in the triglyceride and cholesterol level in men before and after lockdown whereas the level of HDL did not show any significant variation.

Conclusions: From above study it may be concluded that though lockdown is somehow able to control the rapid spread of the virus but it has negative effect on the lipid profile and indirectly cardiovascular health of a man.


Lipid profile, COVID-19, Lockdown, Social isolation

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BBC News. Fact sheet: Coronavirus: India enters total lockdown after spike in cases. Available at: Accessed on 25 May 2021.

House JS, Landis KR, Umberson D. Social relationships and health. Science. 1988;241(4865):540-5.

Lett HS, Blumenthal JA, Babyak MA, Strauman TJ, Robins C, Sherwood A. Social support and coronary heart disease: epidemiologic evidence and implications for treatment. Psychosom Med. 2005;67(6):869-78.

Cohen S, Wills TA. Stress, social support, and the buffering hypothesis. Psychol Bull. 1985;98(2):310-57.

Uchino BN, Cacioppo JT, Kiecolt-Glaser JK. The relationship between social support and physiological processes: a review with emphasis on underlying mechanisms and implications for health. Psychol Bull. 1996;119(3):488-531.

Ramsay S, Ebrahim S, Whincup P, Papacosta O, Morris R, Lennon L, et al. Social engagement and the risk of cardiovascular disease mortality: Results of a prospective population-based study of older men. Ann Epidemiol. 2008;18(6):476-83.

Mackay J, Mensah G. The atlas of heart disease and stroke. 1 ed. Geneva: World Health Organization; 2004.

Reddy KS, Shah B, Varghese C, Ramadoss A. Responding to the threat of chronic diseases in India. Lancet. 2005;366(9498):1744-9.

The expert panel. Report of the National cholesterol education program expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Arch Intern Med. 1988;148(1):36-69.

Hunt SC, Hasstedt SJ, Kuida H, Stults BM, Hopkins PN, Williams RR. Genetic heritability and common environmental components of resting and stressed blood pressures, lipids, and body mass index in Utah pedigrees and twins. Am J Epidemiol. 1989;129(3):625-38.

Patterson SM, Gottdiener JS, Hecht G, Vargot S, Krantz DS. Effects of acute mental stress on serum lipids: mediating effects of plasma volume. Psychosom Med. 1993;55(6):525-32.

Dimsdale JE, Herd JA. Variability of plasma lipids in response to emotional arousal. Psychosom Med. 1982;44(5):413-30.

Prospective Studies Collaboration, Lewington S, Whitlock G, Clarke R, Sherliker P, Emberson J, et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55000 vascular deaths. Lancet. 2007;370(9602):1829-39.

Toth PP, Barter PJ, Rosenson RS, Boden WE, Chapman MJ, Cuchel M, et al. High-density lipoproteins: a consensus statement from the National lipid association. J Clin Lipidol. 2013;7(5):484-525.

Goff DC, Lloyd-Jones DM, Bennett G, Coady S, D'Agostino RB, Gibbons R, et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American college of cardiology/American heart association task force on practice guidelines. Circulation. 2014;129:49-73.

Nordestgaard BG, Wootton R, Lewis B. Selective retention of VLDL, ODL, and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo. Molecular size as a determinant of fractional loss from the intima-inner media. Arterioscler Thromb Vasc Biol. 1995;15(4):534-42.

Freiberg JJ, Tybjaerg-Hansen A, Jensen JS, Nordestgaard BG. Non fasting triglycerides and risk of ischemic stroke in the general population. JAMA. 2008;300(18):2142-52.

Method Manual. Cobas Integra, 400/700/800. CREJC. 2008;5(3):3.

Screening for lipid disorders in adults: recommendation statement. Am Fam Physician. 2016;94(12).

Berkman LF, Blumenthal J, Burg M, Carney RM, Catellier D, Cowan MJ, et al. Effects of treating depression and low perceived social support on clinical events after myocardial infarction: The enhancing recovery in coronary heart disease patients (ENRICHD) randomized trial. JAMA. 2003;289(23):3106-16.

Dochi M, Suwazono Y, Sakata K, Okubo Y, Oishi M, Tanaka K, et al. Shift work is a risk factor for increased total cholesterol level: a 14-year prospective cohort study in 6886 male workers. Occup Environ Med. 2009;66(9):592-7.

Mosendane T, Mosendane T, Raal FJ. Shift work and its effects on the cardiovascular system. Cardiovasc J Afr. 2008;19(4):210-5.

Stoney CM, Matthews KA, McDonald RH, Johnson CA. Sex differences in lipid, lipoprotein, cardiovascular, and neuroendocrine responses to acute stress. Psychophysiology. 1988;25(6):645-56.

Doornen LJPV, Snieder H, Boomsma DI. Serum lipids and cardiovascular reactivity to stress. Biol Psychol. 1998;47(3):279-97.

Steptoe A, Brydon L. Associations between acute lipid stress responses and fasting lipid levels 3 years later. Health Psychol. 2005;24(6):601-7.

Ben-Shlomo Y, Smith GD, Shipley M, Marmot MG. Magnitude and causes of mortality differences between married and unmarried men. J Epidemiol Community Health. 1993;47(3):200-5.

Lund R, Holstein BE, Osler M. Marital history from age 15 to 40 years and subsequent 10-year mortality: a longitudinal study of Danish males born in 1953. Int J Epidemiol. 2004;33(2):389-97.