DOI: http://dx.doi.org/10.18203/issn.2454-2156.IntJSciRep20213695

Brain networks and medical education

Sheena Prineethi, Rose Dawn Bharath, Thamodharan A., Sunithi Mani

Abstract


Background: There has been significant progress in understanding the human brain with the development of modalities like functional magnetic resonance imaging (fMRI), positron emission tomography (PET) etc. Education is an important source of intellectual, emotional and cultural stimulus to the brain. In this resting fMRI study, we aim to map out specific regions in the brain in which changes occur relating to memory, language, motor, behavioural and cognitive functions after five years of undergraduate medical education and how this knowledge can bring us closer to understanding the brain and its functions and applications in clinical practice.

Methods: A total number of 48 normal, healthy medical students from our medical college were included in the study, and were divided into two groups, the first group completed five years of under-graduate medical training and the second group consisted of individuals who had only 4 months of exposure to medical training. Resting state fMRI study was performed and seed-to-voxel based functional connectivity analysis method was used to derive between group differences

Results: Out of the 48, 13 played one or more sport professionally, 8 were musically oriented with skills to play one or more musical instrument professionally and 9 had other talents (2-Good academic, 2-theatre, 3-dancing, 2-art like pottery and painting).

Conclusions: There were significant differences in the right inferior temporal gyrus which is the seat of many cognitive functions like language, emotion and memory and the left cerebellar hemisphere, which is known to play a role in fine motor functions, language and visual learning.


Keywords


Functional MRI, Resting state networks, Medical education, Cognition

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References


Greicius MD, Flores BH, Menon V, Glover GH, Solvason HB, Kenna H et al. Resting-State Functional Connectivity in Major Depression: Abnormally Increased Contributions from Subgenual Cingulate Cortex and Thalamus. Biol Psychiatry. 2007;62(5):429-37.

Li S-J, Li Z, Wu G, Zhang M-J, Franczak M, Antuono PG. Alzheimer Disease: Evaluation of a Functional MR Imaging Index as a Marker. Radiology. 2002;225(1):253.

Lowe MJ, Phillips MD, Lurito JT, Mattson D, Dzemidzic M, Mathews VP. Multiple Sclerosis: Low-Frequency Temporal Blood Oxygen Level–Dependent Fluctuations Indicate Reduced Functional Connectivity-Initial Results. Radiology. 2002;224(1):184-92.

He BJ, Snyder AZ, Vincent JL, Epstein A, Shulman GL, Corbetta M. Breakdown of Functional Connectivity in Frontoparietal Networks Underlies Behavioral Deficits in Spatial Neglect. Neuron. 2007;53(6):905-18.

Bharath RD, Sinha S, Panda R, Raghavendra K, George L, Chaitanya G et al. Seizure Frequency Can Alter Brain Connectivity: Evidence from Resting-State fMRI. Am J Neuroradiol. 2015;36(10):1890-8.

Posner MI, Rothbart MK. Influencing brain networks: implications for education. Trends Cogn Sci. 2005;9(3):99-103.

Wittrock MC. Generative Learning Processes of the Brain. Educ Psychol. 1992;27(4):531-41.

Fischer KW. Mind, Brain, and Education: Building a Scientific Groundwork for Learning and Teaching. Mind Brain Educ. 2009;3(1):3-16.

Lewis CM, Baldassarre A, Committeri G, Romani GL, Corbetta M. Learning sculpts the spontaneous activity of the resting human brain. Proc Natl Acad Sci USA. 2009;106(41):17558-63.

Wu K, Taki Y, Sato K, Hashizume H, Sassa Y, Takeuchi H et al. Topological Organization of Functional Brain Networks in Healthy Children: Differences in Relation to Age, Sex, and Intelligence. PLoS one. 2013;8:2.

Floyer-Lea A, Matthews PM. Distinguishable Brain Activation Networks for Short- and Long-Term Motor Skill Learning. J Neurophysiol. 2005;94(1):512-8.

Dehaene S, Pegado F, Braga LW, Ventura P, Filho GN, Jobert A et al. How Learning to Read Changes the Cortical Networks for Vision and Language. Science. 2010;330(6009):1359-64.

Tzourio-Mazoyer B, Landeau D, Papathanassiou F, Crivello O, Étard N, Delcroix B et al. Automated Anatomical Labelling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain. Neuro image. 2002;15:273-89.

Hodges JR, Patterson K, Oxbury S, Funnell E. Semantic dementia progressive fluent aphasia with temporal lobe atrophy. Brain. 1992;115(6):1783-806.

Klüver H, Bucy PC. Preliminary analysis of functions of the temporal lobes in monkeys. Arch Neurol Psychiatry. 1939;42(6):979-1000.

MacLean PD. The brain in relation to empathy and medical education. J Nervous Mental Disease. J Nerv Ment Dis. 1967;144(5):374-82

Henson RNA, Shallice T, Dolan RJ. Right prefrontal cortex and episodic memory retrieval: A functional MRI test of the monitoring hypothesis. Brain Oxf. 1999;122(7):1367-81.

Fletcher PC, Shallice T, Frith CD, Frackowiak RSJ, Dolan RJ. The functional roles of prefrontal cortex in episodic memory: II. Retrieval. Brain Oxf. 1998;121(7):1249.

Buchel C, Coull JT, Friston J. The predictive value of changes in effective connectivity for human learning. Sci Wash. 1999;283(5407):1538-41.

Milner B, Johnsrude I, Crane J. Right medial temporal-lobe contribution to object–location memory. Philos Trans R Soc Lond B Biol Sci. 1997;352(1360):1469-74.

Köhler S, Moscovitch M, Winocur G, Houle S, McIntosh AR. Networks of domain-specific and general regions involved in episodic memory for spatial location and object identity. Neuropsychologia. 1998;36(2):129-42.

Smith ML, Milner B. The role of the right hippocampus in the recall of spatial location. Neuropsychologia. 1981;19(6):781-93.

Functional role of the supplementary and pre-supplementary motor areas-ProQuest. Available at: https://search.proquest.com/openview/a6c16be842acfa20cc24418fddfaa161/1?pqorigsite=gscholar&cbl=44265. Accessed on Aug 15, 2017.

Fried I, Katz A, McCarthy G, Sass KJ, Williamson P, Spencer SS et al. Functional organization of human supplementary motor cortex studied by electrical stimulation. J Neurosci. 1991;11(11):3656-66.

Goldberg G. Supplementary motor area structure and function: Review and hypotheses. Behav Brain Sci. 1985;8(4):567-88.

Ferrandez AM, Hugueville L, Lehéricy S, Poline JB, Marsault C, Pouthas V. Basal ganglia and supplementary motor area subtend duration perception: an fMRI study. NeuroImage. 2003;19(4):1532-44.

Ridderinkhof KR, Ullsperger M, Crone EA, Nieuwenhuis S. The Role of the Medial Frontal Cortex in Cognitive Control. Science. 2004;306(5695):443-7.

Diamond A. Close Interrelation of Motor Development and Cognitive Development and of the Cerebellum and Prefrontal Cortex. Child Dev. 2000;71(1):44-56.

Ghez C, Fahn S. The cerebellum. Princ Neural Sci. 1985 Available at: http://ci.nii.ac.jp/naid/10016 130496/. Accessed on Aug 15, 2019.

Leiner HC, Leiner AL, Dow RS. Cognitive and language functions of the human cerebellum. Trends Neurosci. 1993;16(11):444-7.

Schmahmann JD. An Emerging Concept. JAMA Neurology. The JAMA Network. Arch Neurol. 1991;48(11):1178-87.

Schmahmann JD, Pandya DN. Pre-lunate, occipitotemporal, and para-hippocampal projections to the basis points in rhesus monkey. J Comp Neurol. 1993;337(1):94-112.

Vilensky JA, Van Hoesen GW. Corticopontine projections from the cingulate cortex in the rhesus monkey. Brain Res. 1981;205(2):391-5.

Barker WW, Yoshii F, Loewenstein DA, Chang JY, Apicella A, Pascal S et al. Cerebrocerebellar Relationship during behavioral Activation: A PET Study. J Cereb Blood Flow Metab. 1991;11(1):48-54.

Arenaza-Urquijo EM, Landeau B, La Joie R, Mevel K, Mézenge F, Perrotin A et al. Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders. Neuro Image. 2013;83:450-7.

Primate anterior cingulate cortex: where motor control, drive and cognition interface-ProQuest. Available at: https://search.proquest.com/open view/241643074aa9caba173a2910f5ef1797/1?pqorigsite=gscholar&cbl=44265. Accessed on Aug 17, 2017.

Van de Ven VG, Formisano E, Prvulovic D, Roeder CH, Linden DEJ. Functional connectivity as revealed by spatial independent component analysis of fMRI measurements during rest. Hum Brain Mapp. 2004;22(3):165-78.

Waites AB, Stanislavsky A, Abbott DF, Jackson GD. Effect of prior cognitive state on resting state networks measured with functional connectivity. Hum Brain Mapp. 2005;24(1):59-68.

Posner MI, Rothbart MK. Influencing brain networks: implications for education. Trends Cogn Sci. 2005;9jvu(3):99-10.

Lewis CM, Baldassarre A, Committeri G, Romani GL, Corbetta M. Learning sculpts the spontaneous activity of the resting human brain. Proc Natl Acad Sci USA. 2009;106(41):17558-63.